Tratamiento de Onicomicosis
Fractional carbon-dioxide (CO2) laser-assisted topical therapy for the treatment of onychomycosis.
Bhatta, A.K.; Keyal, U.; Huang, X.; Zhao, J.J.
Vol. 74
Nr. 5
Página: 916
- 23
Fecha de publicación: 01/05/2016
Resumen:
BACKGROUND:
Inability of topical medications to penetrate via nail plate brings a
great challenge to clinicians in treating onychomycosis. Furthermore,
oral medications are not appropriate for all patients because of drug
interactions, adverse effects, and contraindications. OBJECTIVE: We
sought to evaluate the clinical efficacy of fractional carbon-dioxide
laser-assisted topical therapy for onychomycosis. METHODS: In total, 75
patients with 356 onychomycotic nails confirmed by mycologic examination
were included in this study. All the affected nails received 3 sessions
of laser therapy at 4-week intervals and once-daily application of
terbinafine cream for 3 months. RESULTS: In all, 94.66% and 92% of the
treated patients were potassium hydroxide and culture negative,
respectively, after 3 months of treatment. However, only 84% and 80%
were potassium hydroxide and culture negative, respectively, at 6 months
of follow-up. Using Scoring Clinical Index for Onychomycosis electronic
calculator, 73.33% of the patients scored higher than 6 and 26.66% of
the patients scored 6 or less. Those who scored more than 6 were
evaluated clinically and 98.18% of them showed response to treatment at
3 months and 78.18% of them at 6 months of follow-up. LIMITATION: Lack
of control group and short duration of follow-up are limitations.
CONCLUSIONS: Fractional carbon-dioxide laser therapy combined with
topical antifungal was found to be effective in the treatment of
onychomycosis. However, randomized clinical studies are needed before it
can be widely used in clinics
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